Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and π⋯π interactions using N-methylacetamide
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چکیده
منابع مشابه
Metal-catalysed halogen exchange reactions of aryl halides.
Aryl halides are common synthetic targets themselves, and also highly versatile synthetic intermediates. Aryl chlorides are much more widely available and easier to synthesise than the other halide derivatives, so the development of effective methods for interconverting aryl halide derivatives would therefore be extremely useful. This article outlines which transformations are particularly desi...
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Halogen bonding interactions between halogenated ligands and proteins were examined using the crystal structures deposited to date in the PDB. The data was analyzed as a function of halogen bonding to main chain Lewis bases, viz. oxygen of backbone carbonyl and backbone amide nitrogen. This analysis also examined halogen bonding to side-chain Lewis bases (O, N, and S) and to the electron-rich a...
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The crystal packing in the structures of various solvent-free (mono)haloanilinium halides involves with one exception the formation of approximately planar hydrophilic regions that contain classical hydrogen bonds N-HþþþX (X = halogen). Common to the substructures of all layers are rings of general graph set Rn2n(4n), involving equal numbers of chloride acceptors and NH2 moieties (two hydrogen ...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2016
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c5md00499c